The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.
Identifieur interne : 000779 ( Main/Exploration ); précédent : 000778; suivant : 000780The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.
Auteurs : Peter Ross [États-Unis] ; Paige S. Nemec [États-Unis] ; Alexander Kapatos [États-Unis] ; Keith R. Miller [États-Unis] ; Jennifer C. Holmes [États-Unis] ; Steven E. Suter [États-Unis] ; Adam S. Buntzman [États-Unis] ; Erik J. Soderblom [États-Unis] ; Edward J. Collins [États-Unis] ; Paul R. Hess [États-Unis]Source :
- Veterinary immunology and immunopathology [ 1873-2534 ] ; 2018.
Descripteurs français
- KwdFr :
- Allèles, Animaux, Antigènes d'histocompatibilité de classe I (génétique), Antigènes d'histocompatibilité de classe I (immunologie), Chiens (génétique), Gènes MHC de classe I, Liaison aux protéines, Lymphocytes T (immunologie), Motifs d'acides aminés, Peptides (), Peptides (immunologie), Protéines virales (), Protéines virales (immunologie), Présentation d'antigène, Virus de la maladie de Carré (), Virus de la maladie de Carré (immunologie), Épitopes (), Épitopes (immunologie).
- MESH :
- génétique : Antigènes d'histocompatibilité de classe I, Chiens.
- immunologie : Antigènes d'histocompatibilité de classe I, Lymphocytes T, Peptides, Protéines virales, Virus de la maladie de Carré, Épitopes.
- Allèles, Animaux, Gènes MHC de classe I, Liaison aux protéines, Motifs d'acides aminés, Peptides, Protéines virales, Présentation d'antigène, Virus de la maladie de Carré, Épitopes.
English descriptors
- KwdEn :
- Alleles, Amino Acid Motifs, Animals, Antigen Presentation, Distemper Virus, Canine (chemistry), Distemper Virus, Canine (immunology), Dogs (genetics), Epitopes (chemistry), Epitopes (immunology), Genes, MHC Class I, Histocompatibility Antigens Class I (genetics), Histocompatibility Antigens Class I (immunology), Peptides (chemistry), Peptides (immunology), Protein Binding, T-Lymphocytes (immunology), Viral Proteins (chemistry), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Epitopes, Peptides, Viral Proteins.
- chemistry : Distemper Virus, Canine.
- genetics : Dogs, Histocompatibility Antigens Class I.
- immunology : Distemper Virus, Canine, Epitopes, Histocompatibility Antigens Class I, Peptides, T-Lymphocytes, Viral Proteins.
- Alleles, Amino Acid Motifs, Animals, Antigen Presentation, Genes, MHC Class I, Protein Binding.
Abstract
Ideally, CD8+ T-cell responses against virally infected or malignant cells are defined at the level of the specific peptide and restricting MHC class I element, a determination not yet made in the dog. To advance the discovery of canine CTL epitopes, we sought to determine whether a putative classical MHC class Ia gene, Dog Leukocyte Antigen (DLA)-88, presents peptides from a viral pathogen, canine distemper virus (CDV). To investigate this possibility, DLA-88*508:01, an allele prevalent in Golden Retrievers, was expressed as a FLAG-tagged construct in canine histiocytic cells to allow affinity purification of peptide-DLA-88 complexes and subsequent elution of bound peptides. Pattern analysis of self peptide sequences, which were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS), permitted binding preferences to be inferred. DLA-88*508:01 binds peptides that are 9-to-12 amino acids in length, with a modest preference for 9- and 11-mers. Hydrophobic residues are favored at positions 2 and 3, as are K, R or F residues at the C-terminus. Testing motif-matched and -unmatched synthetic peptides via peptide-MHC surface stabilization assay using a DLA-88*508:01-transfected, TAP-deficient RMA-S line supported these conclusions. With CDV infection, 22 viral peptides ranging from 9-to-12 residues in length were identified in DLA-88*508:01 eluates by LC-MS/MS. Combined motif analysis and surface stabilization assay data suggested that 11 of these 22 peptides, derived from CDV hemagglutinin, large polymerase, matrix, nucleocapsid, and V proteins, were processed and presented, and thus, potential targets of anti-viral CTL in DLA-88*508:01-bearing dogs. The presentation of diverse self and viral peptides indicates that DLA-88 is a classical MHC class Ia gene.
DOI: 10.1016/j.vetimm.2018.01.005
PubMed: 29475511
Affiliations:
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Soderblom</name><affiliation wicri:level="1"><nlm:affiliation>Proteomics Core Facility, Institute for Genome Science and Policy, Duke University School of Medicine, Durham, NC, 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Core Facility, Institute for Genome Science and Policy, Duke University School of Medicine, Durham, NC, 27710</wicri:regionArea><wicri:noRegion>27710</wicri:noRegion></affiliation></author><author><name sortKey="Collins, Edward J" sort="Collins, Edward J" uniqKey="Collins E" first="Edward J" last="Collins">Edward J. Collins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599</wicri:regionArea><wicri:noRegion>27599</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Paul R" sort="Hess, Paul R" uniqKey="Hess P" first="Paul R" last="Hess">Paul R. Hess</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA. Electronic address: paul_hess@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29475511</idno><idno type="pmid">29475511</idno><idno type="doi">10.1016/j.vetimm.2018.01.005</idno><idno type="wicri:Area/PubMed/Corpus">000993</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000993</idno><idno type="wicri:Area/PubMed/Curation">000993</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000993</idno><idno type="wicri:Area/PubMed/Checkpoint">000740</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000740</idno><idno type="wicri:Area/Ncbi/Merge">001D39</idno><idno type="wicri:Area/Ncbi/Curation">001D39</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D39</idno><idno type="wicri:Area/Main/Merge">000782</idno><idno type="wicri:Area/Main/Curation">000779</idno><idno type="wicri:Area/Main/Exploration">000779</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.</title><author><name sortKey="Ross, Peter" sort="Ross, Peter" uniqKey="Ross P" first="Peter" last="Ross">Peter Ross</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author><author><name sortKey="Nemec, Paige S" sort="Nemec, Paige S" uniqKey="Nemec P" first="Paige S" last="Nemec">Paige S. Nemec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author><author><name sortKey="Kapatos, Alexander" sort="Kapatos, Alexander" uniqKey="Kapatos A" first="Alexander" last="Kapatos">Alexander Kapatos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Keith R" sort="Miller, Keith R" uniqKey="Miller K" first="Keith R" last="Miller">Keith R. Miller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599</wicri:regionArea><wicri:noRegion>27599</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, Jennifer C" sort="Holmes, Jennifer C" uniqKey="Holmes J" first="Jennifer C" last="Holmes">Jennifer C. Holmes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author><author><name sortKey="Suter, Steven E" sort="Suter, Steven E" uniqKey="Suter S" first="Steven E" last="Suter">Steven E. Suter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author><author><name sortKey="Buntzman, Adam S" sort="Buntzman, Adam S" uniqKey="Buntzman A" first="Adam S" last="Buntzman">Adam S. Buntzman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunobiology, University of Arizona, Tucson, AZ, 85724, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunobiology, University of Arizona, Tucson, AZ, 85724</wicri:regionArea><wicri:noRegion>85724</wicri:noRegion></affiliation></author><author><name sortKey="Soderblom, Erik J" sort="Soderblom, Erik J" uniqKey="Soderblom E" first="Erik J" last="Soderblom">Erik J. Soderblom</name><affiliation wicri:level="1"><nlm:affiliation>Proteomics Core Facility, Institute for Genome Science and Policy, Duke University School of Medicine, Durham, NC, 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Core Facility, Institute for Genome Science and Policy, Duke University School of Medicine, Durham, NC, 27710</wicri:regionArea><wicri:noRegion>27710</wicri:noRegion></affiliation></author><author><name sortKey="Collins, Edward J" sort="Collins, Edward J" uniqKey="Collins E" first="Edward J" last="Collins">Edward J. Collins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599</wicri:regionArea><wicri:noRegion>27599</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Paul R" sort="Hess, Paul R" uniqKey="Hess P" first="Paul R" last="Hess">Paul R. Hess</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607, USA. Electronic address: paul_hess@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607</wicri:regionArea><wicri:noRegion>27607</wicri:noRegion></affiliation></author></analytic><series><title level="j">Veterinary immunology and immunopathology</title><idno type="eISSN">1873-2534</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Amino Acid Motifs</term><term>Animals</term><term>Antigen Presentation</term><term>Distemper Virus, Canine (chemistry)</term><term>Distemper Virus, Canine (immunology)</term><term>Dogs (genetics)</term><term>Epitopes (chemistry)</term><term>Epitopes (immunology)</term><term>Genes, MHC Class I</term><term>Histocompatibility Antigens Class I (genetics)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Peptides (chemistry)</term><term>Peptides (immunology)</term><term>Protein Binding</term><term>T-Lymphocytes (immunology)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Animaux</term><term>Antigènes d'histocompatibilité de classe I (génétique)</term><term>Antigènes d'histocompatibilité de classe I (immunologie)</term><term>Chiens (génétique)</term><term>Gènes MHC de classe I</term><term>Liaison aux protéines</term><term>Lymphocytes T (immunologie)</term><term>Motifs d'acides aminés</term><term>Peptides ()</term><term>Peptides (immunologie)</term><term>Protéines virales ()</term><term>Protéines virales (immunologie)</term><term>Présentation d'antigène</term><term>Virus de la maladie de Carré ()</term><term>Virus de la maladie de Carré (immunologie)</term><term>Épitopes ()</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes</term><term>Peptides</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Distemper Virus, Canine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dogs</term><term>Histocompatibility Antigens Class I</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term><term>Chiens</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term><term>Lymphocytes T</term><term>Peptides</term><term>Protéines virales</term><term>Virus de la maladie de Carré</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Distemper Virus, Canine</term><term>Epitopes</term><term>Histocompatibility Antigens Class I</term><term>Peptides</term><term>T-Lymphocytes</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Amino Acid Motifs</term><term>Animals</term><term>Antigen Presentation</term><term>Genes, MHC Class I</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Animaux</term><term>Gènes MHC de classe I</term><term>Liaison aux protéines</term><term>Motifs d'acides aminés</term><term>Peptides</term><term>Protéines virales</term><term>Présentation d'antigène</term><term>Virus de la maladie de Carré</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ideally, CD8+ T-cell responses against virally infected or malignant cells are defined at the level of the specific peptide and restricting MHC class I element, a determination not yet made in the dog. To advance the discovery of canine CTL epitopes, we sought to determine whether a putative classical MHC class Ia gene, Dog Leukocyte Antigen (DLA)-88, presents peptides from a viral pathogen, canine distemper virus (CDV). To investigate this possibility, DLA-88*508:01, an allele prevalent in Golden Retrievers, was expressed as a FLAG-tagged construct in canine histiocytic cells to allow affinity purification of peptide-DLA-88 complexes and subsequent elution of bound peptides. Pattern analysis of self peptide sequences, which were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS), permitted binding preferences to be inferred. DLA-88*508:01 binds peptides that are 9-to-12 amino acids in length, with a modest preference for 9- and 11-mers. Hydrophobic residues are favored at positions 2 and 3, as are K, R or F residues at the C-terminus. Testing motif-matched and -unmatched synthetic peptides via peptide-MHC surface stabilization assay using a DLA-88*508:01-transfected, TAP-deficient RMA-S line supported these conclusions. With CDV infection, 22 viral peptides ranging from 9-to-12 residues in length were identified in DLA-88*508:01 eluates by LC-MS/MS. Combined motif analysis and surface stabilization assay data suggested that 11 of these 22 peptides, derived from CDV hemagglutinin, large polymerase, matrix, nucleocapsid, and V proteins, were processed and presented, and thus, potential targets of anti-viral CTL in DLA-88*508:01-bearing dogs. The presentation of diverse self and viral peptides indicates that DLA-88 is a classical MHC class Ia gene.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Ross, Peter" sort="Ross, Peter" uniqKey="Ross P" first="Peter" last="Ross">Peter Ross</name></noRegion><name sortKey="Buntzman, Adam S" sort="Buntzman, Adam S" uniqKey="Buntzman A" first="Adam S" last="Buntzman">Adam S. Buntzman</name><name sortKey="Collins, Edward J" sort="Collins, Edward J" uniqKey="Collins E" first="Edward J" last="Collins">Edward J. Collins</name><name sortKey="Hess, Paul R" sort="Hess, Paul R" uniqKey="Hess P" first="Paul R" last="Hess">Paul R. Hess</name><name sortKey="Holmes, Jennifer C" sort="Holmes, Jennifer C" uniqKey="Holmes J" first="Jennifer C" last="Holmes">Jennifer C. Holmes</name><name sortKey="Kapatos, Alexander" sort="Kapatos, Alexander" uniqKey="Kapatos A" first="Alexander" last="Kapatos">Alexander Kapatos</name><name sortKey="Miller, Keith R" sort="Miller, Keith R" uniqKey="Miller K" first="Keith R" last="Miller">Keith R. Miller</name><name sortKey="Nemec, Paige S" sort="Nemec, Paige S" uniqKey="Nemec P" first="Paige S" last="Nemec">Paige S. Nemec</name><name sortKey="Soderblom, Erik J" sort="Soderblom, Erik J" uniqKey="Soderblom E" first="Erik J" last="Soderblom">Erik J. Soderblom</name><name sortKey="Suter, Steven E" sort="Suter, Steven E" uniqKey="Suter S" first="Steven E" last="Suter">Steven E. Suter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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